Alzheimer's Disease, Disintegrating Microtubule
Neurofibrillary Tangles (NFTs) are aggregates of a microtubule-associated hyperphosphorylated protein (known as "tau") that are most commonly known as a primary marker of Alzheimer's disease. The traditional understanding is that when tau becomes hyperphosphorylated, it is unable to bind with the microtubules, which allows them to become unstable and begin disintegrating. Alzheimer's disease (AD), also known as Alzheimer disease, or just Alzheimer's, accounts for 60% to 70% of cases of dementia. It is a chronic neurodegenerative disease that usually starts slowly and gets worse over time. The most common early symptom is difficulty in remembering recent events (short-term memory loss). As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, not managing self care, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the average life expectancy following diagnosis is three to nine years. About 70% of the risk is believed to be genetic with many genes usually involved.
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