In 64 BC Zeugma was conquered and ruled by the Roman Empire and with this shift the name of the city was changed into Zeugma, meaning "bridge-passage" or "bridge of boats". During Roman rule, the city became one of the attractions in the region, due to its commercial potential originating from its geo-strategic location because the city was on the Silk Road connecting Antioch to China with a quay or pontoon bridge across the river Euphrates which was the border with the Persian Empire until the late 2nd century.

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