Transmission electron micrograph (TEM) of Gram-negative Orientia tsutsugamushi rickettsial micro-organisms
Transmission electron micrograph (TEM) of a murine peritoneal mesothelial cell that was infected with multiple free cytoplasmic Gram-negative Orientia tsutsugamushi rickettsial micro-organisms. One pathogen can be seen as it was "budding" from the luminal cell surface, and it is still covered by a third layer, which represents the host cell's plasma membrane. The mesothelium is a cell layer that lines the cavities of the body, and in the abdominopelvic cavities it is also referred to as the peritoneum. Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi. The disease occurs mainly in the large triangular region extending from Japan in the north to Australia in the southwest and the South Pacific Islands in the southeast. Humans are infected by the bite of the larva of the trombiculid mite harboring O. tsutsugamushi. This pathogen attacks endothelial cells resulting in vasculitis. The clinical manifestations are characterized by a papular rash, headache, fever, chills, and an eschar at the site of the chigger bite. The disease can be tested serologically
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Photo credit: © Scott Camazine / Alamy / Afripics
License: Licensed
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Keywords: electron, gram-negative, infection, medicine, micro-organisms, micrograph, orientia, rickettsial, tem, transmission, tsutsugamushi
