The effects of inanition and The effects of inanition and malnutrition upon growth and structure effectsofinaniti00jack Year: 1925 196 INANITION AND MALNUTRITION group of the anterior horn cells (Fig. 61). In these cells the Nissl granules undergo chromatolysis, and the nucleus appears swollen. Schaffer ('97) noted that the chromatolytic changes in the anterior horn cells of fasting rabbits are more intensive, and accompanied by greater vacuolation of the cytoplasm, in total inanition, than with water only. The nucleus also becomes deeply stained throughout. Jacobsohn O97) failed to confirm S
The effects of inanition and The effects of inanition and malnutrition upon growth and structure effectsofinaniti00jack Year: 1925 196 INANITION AND MALNUTRITION group of the anterior horn cells (Fig. 61). In these cells the Nissl granules undergo chromatolysis, and the nucleus appears swollen. Schaffer ('97) noted that the chromatolytic changes in the anterior horn cells of fasting rabbits are more intensive, and accompanied by greater vacuolation of the cytoplasm, in total inanition, than with water only. The nucleus also becomes deeply stained throughout. Jacobsohn O97) failed to confirm Schaffer, however, and Placzek ('99) found no nuclear changes, but merely chromatolysis (also some degeneration in the posterior column by the Marchi method). The work on nerve cell changes during inanition up to 1898 was reviewed by Barbacci ('99), Robertson ('99), and more recently by Marinesco ('09). Further studies on the anterior horn cells of fasting rabbits and guinea pigs were made by Marchand and Vurpas ('01), using various stains (picrocarmine, haematoxylin, Nissl's, Pal-Weigert, Marchi and Golgi methods). The changes are described in 3 stages, with intermediate forms: (1) cell size unchanged; cytoplasm becomes decolorized, with pale Nissl gran- ules ; nucleus central and unstained, with distinct nucleolus; (2) cell somewhat shrunken, with fewer and thicker processes; Nissl bodies finely granular; nucleus eccentric and irregular in form, deeply stain- ing with nucleolus still distinct; (3) Fig. 61.âNerve cells from the ventral horn of preceding changes more extreme, the spinal cord in the rabbit, stained by Nissl's â¢.â â ⢠, n .-,. â . method, a. cell from normal control; b, c, cells show- Wlth 'Tegular Cell Outline, shorter ing the progressive disintegration of the Nissl bodies and less numerous Cell processes; after 5 to 7 days of total inanition. (Ganfini '97.) 1 1 . ⢠⢠1 deeply-staining, non-granular, vac- uolated cytoplasm; nucleus atrophied and d
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