Stem cell research. Researcher working with stem cells in an embryology laboratory. This team of scientists from Cambridge University, UK, have create
Stem cell research. Researcher working with stem cells in an embryology laboratory. This team of scientists from Cambridge University, UK, have created a structure resembling a mouse embryo in culture, using two types of stem cells and a 3D scaffold on which they can grow. Previous attempts to grow embryo-like structures using only embryonic stem cells (ESCs) have had limited success. This is because early embryo development requires the interaction and close co-ordination of ESCs with the two other types of stem cells - trophoblast stem cells (TSCs), which will form the placenta, and primitive endoderm stem cells that will form the 'yolk sac'. The teams findings have led to a completely revised model for peri-implantation morphogenesis in which extracellular matrix (ECM) proteins trigger the self-organisation of the embryo's stem cells.
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Photo credit: © LEWIS HOUGHTON/SCIENCE PHOTO LIBRARY / Alamy / Afripics
License: Licensed
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